Peptide Nasal Sprays

 Peptide nasal sprays are a convenient way to deliver peptide therapy straight into the bloodstream, bypassing the digestive system. This means that the healing compounds will be absorbed faster and can begin to work at a more accelerated pace. These peptides are used for a variety of reasons, from helping patients recover from mold or chronic inflammatory response syndrome (CIRS) to improving athletic performance.

Peptides are short-chain amino acids that act as messengers in the body. They bind to receptors on cells and trigger a specific response. Depending on the peptide and the individual, these responses can include stimulating growth hormone production, reducing insulin sensitivity, or boosting brain function. Peptide therapy can also reduce inflammation, improve sleep quality, enhance mood, and prevent chronic illness.

Most peptides are administered in the form of injections, but this route can lead to unwanted side effects such as swelling, redness, pain, and headache. A peptide nasal spray, on the other hand, offers a much more targeted delivery of the compound and is far less likely to cause any unwanted side effects.

In fact, nasal administration of peptides can significantly increase the levels of the compound in the bloodstream and CSF. This is because the drug does not have to pass through the digestive tract and the hepatic first-pass effect. In addition, the drugs can reach the brain directly through the olfactory bulb, bypassing the BBB.

A peptide nasal spray is essentially an aerosol that contains the peptide in liquid form. The peptide is mixed with other ingredients to make it easier to deliver through the nasal cavity. The other ingredients, often referred to as excipients, may include preservatives, humectants, and emulsifiers. These ingredients are crucial to ensure the stability and performance of the formulation.

For example, a peptide nasal spray that contains the anti-seizure drug esketamine would contain esketamine in an aqueous solution along with glycerin, sodium benzoate, propylene glycol, FD&C yellow no. 10, and FD&C blue no. 3. This is a very safe and effective formula that can be safely delivered to the nose.

Another peptide nasal spray contains a neuroprotective compound called A1R-CT. It has been shown to tamp down the uncontrolled electrical activity in the brain that leads to seizures and Alzheimer’s. A1R-CT works by inhibiting the protein neurabin, which normally holds back the action of the adenosine 1 receptor in the brain.

Using a peptide nasal spray to deliver A1R-CT into the brain, researchers were able to protect neurons and prevent seizures in animal models of traumatic brain injury and Alzheimer’s. The team hopes that A1R-CT can be translated into a clinical treatment for people who suffer from seizure disorders or Alzheimer’s disease.

While the benefits of peptide nasal sprays are considerable, it is important to consult with a physician before beginning this type of therapy. Some peptides can cause allergic reactions, hormonal imbalances, or interact with certain medications. A physician can evaluate an individual’s medical history and recommend a safe, personalized treatment protocol.